Angiotensinogen

An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.

Also Known As:

Proangiotensin; Renin Substrate Tetradecapeptide; Serpin A8; Renin Substrate; Tetradecapeptide, Renin Substrate; Hypertensinogen; Renin-Substrate; SERPINA8; Angiotensinogen (protein renin substrate)

Pharmalogical Action Categories:

Serine Proteinase Inhibitors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Serpins: 906
    - Angiotensinogen: 1828
  - Protein Precursors: 37
    - Angiotensinogen: 1828
- Peptides: 82426
  - Serpins: 906
    - Angiotensinogen: 1828
  - Oligopeptides: 519
    - Angiotensins: 6068
      - Angiotensinogen: 1828

M Puscas Selected Research

M Puscas Research Topics

Disease

Drug/Important Bio-Agent (IBA)